This is the website for the ongoing graduate course (Winter 2018). We
will meet every Wednesday at 7 p.m. in the main link (in case you didn't notice).
Here is the PDF version. Note that that it does not talk about the presentation option
for evaluation; this is because I originally expected to teach this class in joint sessions with the 4th year
As stated in the first lecture, every student is expected to either
write a review paper on a mutually agreed topic, or give a presentation on a research paper in class.
I realize a review is more work than a presentation, but you will also learn more from it. However, the choice is yours.
Even if you are not sure about the topic, I would appreciate if you could let me know by January 28th whether
your prefer a review or a presentation. This way, I can get a better idea as to how many presentations to accommodate
in the class schedule. I would prefer to have one or at the most two presentations on a given date; I don't want to cram
too many presentations into a single meeting.
Reviews should be not too long, not too short, just right ;) I consider the JBC minireview format a good example of
suitable length and scope. If unsure, feel free to come by for discussion anytime.
You may choose your own topic, but please run it by me before actually starting to work on it. You might
take a look at the topics addressed by the papers listed below; several of them are foci of current resarch interest.
- Girennavar, B. et al. (2007) Potent inhibition of human cytochrome P450 3A4, 2D6,
and 2C9 isoenzymes by grapefruit juice and its furocoumarins. J. Food
This paper was presented by Dominika Gruszecka on February 14th.
- Terés, Silvia et al. (2012) 2-Hydroxyoleate, a nontoxic membrane binding
anticancer drug, induces glioma cell differentiation and autophagy. Proc. Natl.
Acad. Sci. U.S.A. 109:8489-94
This paper will be presented by Hernando Rosales on February 28th.
- Kundur, Avinash R. et al. (2017) Mildly elevated unconjugated bilirubin is
associated with reduced platelet activation-related thrombogenesis and inflammation in
Gilbert's syndrome. Platelets 28:779-785
This paper will be presented by Emir Nazdrajic on February 28th.
- Nakajima, Ken-Ichiro and Wess, Jürgen (2012) Design and functional
characterization of a novel, arrestin-biased designer G protein-coupled receptor. Mol
This paper will be presented by Volition La on March 7th.
- Wehbi, Vanessa L. et al. (2013) Noncanonical GPCR signaling arising from a PTH
receptor-arrestin-Gβγ complex. Proc Natl Acad
Sci U S A 110:1530-1535
This paper will be presented by Dalia Naser on March 14th.
- Friemel, Chris M. et al. (2014) The CB1 receptor as an important mediator of
hedonic reward processing. Neuropsychopharmacology 39:2387-96
This paper will be presented by Ashkan Hashemi on March 21st.
- Chandrasekera, P. Charukeshi et al. (2013) Adenosine A1 receptors heterodimerize
with β1- and β2-adrenergic receptors creating novel receptor complexes with
altered G protein coupling and signaling.Cell Signal
This paper will be presented by Yibo Liu on March 21st.
- Hermanson, Daniel J. et al. (2013) Substrate-selective COX-2 inhibition decreases
anxiety via endocannabinoid activation. Nat
This paper will be presented by Taylor Urquhart on March 28th.
- Leger, Andrew J. et al. (2006) Blocking the protease-activated receptor 1-4
heterodimer in platelet-mediated thrombosis. Circulation
This paper will be presented by Jordan Rydzik on March 28th.
- Fedorova, Olga V. et al. (2008) Monoclonal antibody to an endogenous
bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and
lowers blood pressure in NaCl-sensitive hypertension. J Hypertens
This paper will be presented by Brian Youden on April 4th.
I hope you will find time to have a look at the papers to be presented ahead of the class, so that we can have a bit of questions and answers after each presentation.
Papers for presentations
Here are some papers that appear suitable for presentation – first come, first serve.
- Bannister, Roger A. et al. (2016) Distinct Components of Retrograde Ca(V)1.1-RyR1
Coupling Revealed by a Lethal Mutation in RyR1. Biophys. J.
- Barber, Annika F. et al. (2011) Molecular mapping of general anesthetic sites in a
voltage-gated ion channel. Biophys J 101:1613-1622
As noted earlier, you may also hunt for a paper yourself, but please check with me before getting to work on it.
A presentation should last approximately 15-20 minutes. It should try to focus on the key findings of the study; a good general introduction to the topic that puts the study into context for the other students is more important than going over each and every figure or method from the paper. Feel free to discuss your presentation with me ahead of time.
Course notes and slides
These are all available on my website.